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European Conference on Computational Biology 2005


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Pfizer Inc. collaborates with Arity Corporation on two projects which address needs for enterprise-scale software systems to manage and use biomedical ontologies. In designing these systems, we confronted certain challenges, namely

The presence at Pfizer of multiple inter-related and nested ontologies that must be managed in concert; Varying levels of abstraction in a given ontology; The need for "applied ontologies" that fit into current scientific processes; and The need for high precision in order to accurately inference and hypothecate on collected data.

To address these issues we developed guidelines for ontology development and management in biomedical R&D. This paper describes those guidelines and the systems that were developed.
 

2006 International Semantic Web Conference
Workshop for Web Health Care & Life Sciences


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We are interested in the application of semantic web technologies to specific questions in the life sciences. The specific study area is oil biosynthesis in Brassica napus, or oilseed rape, the third leading source of vegetable oil and the second leading source of protein meal according to the UN Food and Agricultural Organization. In principle, a great deal could potentially be learned about the relevant pathways in Brassica by comparison to the much better studied Arabidopsis thaliana, a close relative. Oil biosynthesis is enormously enhanced in Brassica, compared to Arabidopsis, and so comparison of the two genera has the potential to provide substantial insight into what gene families and pathways have been modified or amplified in Brassica to give rise to the observed levels of oil production (up to 50% of seed weight), as well as the differing oil composition.

 

EXPRESSway Brochure

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This brochure describes EXPRESSway and its application to Research Process Optimization.